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In the Krebs cycle, what molecules acquire most of the energy that is released by the oxidation of acetyl CoA?
…., and how many of these molecules are produced during each turn of the cycle?
Thank you.
Krebs Cycle is also known as the Citric Acid Cycle.
The citric acid cycle begins with acetyl-CoA transferring its two-carbon acetyl group to the four-carbon acceptor compound (oxaloacetate) to form a six-carbon compound (citrate).
The citrate then goes through a series of chemical transformations, losing first one, then a second carboxyl group as CO2. The carbons lost as CO2 originate from what was oxaloacetate, not directly from acetyl-CoA. The carbons donated by acetyl-CoA become part of the oxaloacetate carbon backbone after the first turn of the citric acid cycle. Loss of the acetyl-CoA-donated carbons as CO2 requires several turns of the citric acid cycle. However, because of the role of the citric acid cycle in anabolism, they may not be lost since many TCA cycle intermediates are also used as precursors for the biosynthesis of other molecules.[4]
Most of the energy made available by the oxidative steps of the cycle is transferred as energy-rich electrons to NAD+, forming NADH. For each acetyl group that enters the citric acid cycle, three molecules of NADH are produced.
Electrons are also transferred to the electron acceptor FAD, forming FADH2.
At the end of each cycle, the four-carbon oxaloacetate has been regenerated, and the cycle continues.
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April 12th, 2010
Angie 
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